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These tails are topic to several publish-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). |
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The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and which are structurally not associated to SET-area proteins 4 - 6 Latest work suggests that SET-area-containing proteins methylate a few proteins in addition to histones (see later) |
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